Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans
نویسندگان
چکیده
منابع مشابه
Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway.
The immune system is essential to maintain homeostasis with resident microbial populations, ensuring that the symbiotic host-microbial relationship is maintained. In parallel, commensal microbes significantly shape mammalian immunity at the host mucosal surface, as well as systemically. Candida albicans is an opportunistic pathogen that lives as a commensal on skin and mucosa of healthy individ...
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Neil A. R. Gow,1,a Mihai G. Netea,2,a Carol A. Munro,1 Gerben Ferwerda,2,3 Steven Bates,1 Héctor M. Mora-Montes,1 Louise Walker,1 Trees Jansen,2,3 Liesbeth Jacobs,2,3 Vicky Tsoni,4 Gordon D. Brown,4 Frank C. Odds,1 Jos W. M. Van der Meer,2,3 Alistair J. P. Brown,1 and Bart Jan Kullberg2,3 1School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdo...
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Several pathogens have been described to enter host cells via cholesterol-enriched membrane lipid raft microdomains. We found that disruption of lipid rafts by the cholesterol-extracting agent methyl-β-cyclodextrin or by the cholesterol-binding antifungal drug Amphotericin B strongly impairs the uptake of the fungal pathogen Candida albicans by human monocytes, suggesting a role of raft microdo...
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Fungal infections are becoming increasingly prevalent in the human population and contribute to morbidity and mortality in healthy and immunocompromised individuals respectively. Candida albicans is the most commonly encountered fungal pathogen of humans, and is frequently found on the mucosal surfaces of the body. Host defense against C. albicans is dependent upon a finely tuned implementation...
متن کاملCandida arthritis: cellular immune responses of synovial fluid and peripheral blood lymphocytes to Candida albicans.
A case of septic Candida albicans arthritis of the knee in a patient with systemic candidiasis is presented. Systemic and intra-articular cellular immune responses to C albicans and various bacterial antigens were monitored for 15 weeks. It is shown that the candida induced blastogenesis of synovial fluid lymphocytes was much more stimulated than that of peripheral blood lymphocytes, and that t...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2019
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1801384